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Short answer: A multi-centre field study of Cattle Remedies Uterotone 3-in-1 in 51 dairy cows and buffaloes across seven Indian states has been published in the International Journal of Veterinary Sciences and Animal Husbandry. All 51 animals expelled the placenta within the normal time frame and showed normal lochial discharge, the 40 animals with usable milk records averaged an extra 541 ml/day in early lactation, and no adverse effects were reported. Equally important, and stated plainly here: the study had no control group, it was conducted and funded by us, and it therefore shows what happened — not what would have happened otherwise.
Most product studies in this industry are presented as proof. This one is not proof, and saying so is not modesty — it is what the study design actually permits. We would rather you judged Uterotone 3-in-1 on an honest account of real field data than on a percentage pulled out of context.
It was a prospective, multi-centre, open-label field study run between October 2025 and February 2026 across veterinary centres in Rajasthan, Punjab, Jammu & Kashmir, Bihar, Haryana, Uttar Pradesh and Maharashtra.
All 51 animals (100%) expelled the placenta within the physiological time frame, and all showed normal lochial discharge, indicating satisfactory uterine clearance. Improvement in general wellness was recorded for all animals, and no adverse reactions were reported at any point.
Context for that first figure: retained foetal membranes are reported in roughly 5–15% of dairy cattle globally. In 51 animals you might expect somewhere between three and eight retentions. Seeing none is a genuinely interesting observation. It is not, on its own, evidence of an effect — without a comparison group we cannot know what this particular set of animals, on these particular farms, with veterinarians paying close attention, would have done anyway.
Usable milk yield data existed for 40 of the 51 animals. Among those, the mean increase in early lactation was 541 ± 386 ml/day, with a median and mode of 500 ml/day. The spread matters more than the average:
So the typical animal was around half a litre a day, not the two litres at the top of the range. Roughly 72% fell between 100 and 500 ml/day. Half a litre a day through early lactation is commercially meaningful on a smallholding, and we think it is more useful to tell you the median than to quote the maximum.
Fat content improvement was reported in 45 of 51 cases (88.2%). All 51 participating field veterinarians expressed satisfaction with the clinical response and said they would recommend the product for peri-parturient use.
On that last figure, one honest caveat: veterinarian satisfaction in an open-label study where everyone knows what is being given is a measure of practical acceptance, not of efficacy. It tells you experienced practitioners found it workable and worth using. It does not control for expectation.
Set out plainly, because these limitations are real:
The authors' own conclusion is that controlled, randomised, blinded studies with larger samples and concurrent negative controls are warranted. That is the right next step and we intend to pursue it.
A fair reading is this. Across 51 animals in seven states, under ordinary farm conditions rather than research-station conditions, a short peri-parturient course of Uterotone 3-in-1 was followed by uncomplicated placental expulsion and clean uterine recovery in every case, a modest and consistent milk yield gain in early lactation, and no safety problems at a mean total dose of about 900 ml. Fifty-one experienced field veterinarians were satisfied enough to recommend continuing with it.
That is a reasonable basis for considering it as part of a transition-period programme. It is not a basis for expecting it to prevent retained placenta on its own, and no supportive formulation should be used that way. The things that genuinely reduce retained placenta and metritis are calcium management, dry matter intake, hygiene at calving and prompt veterinary attention — we cover them in our guides to the transition period in dairy cattle and retained placenta in the first 24 hours.
Cattle Remedies Uterotone 3-in-1 is a herbal peri-parturient formulation for oral administration before and after calving, developed to support uterine tone, timely expulsion of foetal membranes and early lactation performance. The wider Cattle Remedies uterine range includes Uterotone Liquid and Uterotone DS; our uterine tonic buying guide compares them. Dosage and suitability for a given animal should be decided with your veterinarian.
No, and we would not claim it does. It shows that no retention occurred among 51 treated animals, which is a favourable observation against a 5–15% expected background rate. Proving prevention requires a randomised controlled trial with a concurrent untreated group, which this study did not have and which its authors recommend as the next step.
The median in this study was 500 ml/day in early lactation, with about 72% of animals between 100 and 500 ml/day. The top figure of 2000 ml/day was an outlier in two animals. Response varied with breed, parity, nutrition and baseline yield, so the median is the more honest planning number — and it comes from an uncontrolled study, so treat it as indicative rather than guaranteed.
It is open access under a CC BY-NC-SA 4.0 licence. Full citation: Shamim R, Agrawal H, Dar FA, Singh S, Shukla R, Singh A. Evaluation of uterotone 3-in-1 for improvement of peri-parturient health, uterine recovery and milk production in dairy animals: a multi-centre field study. International Journal of Veterinary Sciences and Animal Husbandry. 2026;11(6S):76–79. DOI: 10.22271/veterinary.2026.v11.i6Sb.3517.
Disclosure: this study was conducted, authored and sponsored by Makams Industries Pvt. Ltd. / Cattle Remedies. This article is general educational guidance and is not a substitute for veterinary advice. Uterotone 3-in-1 is a supportive formulation and does not replace veterinary diagnosis or treatment of retained placenta, metritis or any other condition.
